luyang dilaw
This blog attempts to present compendium of medical and clinical researches on turmeric, or luyang dilaw. The author believes that the promotion of health need not be expensive. Expensive western-based medicines have infiltrated our market, which majority of Filipino people unable to afford. I am offering this blog for those who believe that herbal medicines can cure or restore their deteriorating health. I can be contacted through my email: luyangdulaw@gmail.com
Thursday, January 28, 2016
Warm Greetings!
When I created this blog three years ago, it did not cross my mind that people would visit and read its contents. From the numerous emails, mostly from European and North America's countries, inquiring herbal and organic products, as well as the intention to help the economically challenged Filipinos through the production of herbal medicines, I will be happy to accommodate your requests.
For sometime, I had been subscribing to organic and herbal medicines. I used to have a cough, part of my genetic defect, that usually lasted a month. Two years ago, someone advised me to take herbal medicines made of alagao and luyang dilaw. The result seems to be positively significant to herbal medicines intake, with just 3-4 days of intake.
The herbal products that I will recommend come from accredited women organization. Hopefully, their herbal products, from 100% honey to herbal medicines, will be posted here soon.
This initiative promotes social entrepreneurship. As a public high school teacher, and appointed designated guidance teacher, I have witnessed how poverty crippled and paralyzed the dreams of my students because of financial incapacity of their parents to send them to school. The women who prepare these herbal medicines are economically deprived. And in some way, you are helping these families survive on daily basis.
Monday, February 25, 2013
CURCUMIN: THE INDIAN
SOLID GOLD
Abstract: Turmeric,
derived from the plant Curcuma longa, is a gold-colored spice commonly used in
the Indian subcontinent, not only for health care but also for the preservation
of food and as a yellow dye for textiles. Curcumin, which gives the yellow
color to turmeric, was first isolated almost two centuries ago, and its
structure as diferuloylmethane was determined in 1910. Since the time of
Ayurveda (1900 bc) numerous therapeutic activities have been assigned to
turmeric for a wide variety of diseases and conditions, including those of the
skin, pulmonary, and gastrointestinal systems, aches, pains, wounds, sprains, and
liver disorders. Extensive research within the last half century has proven that
most of these activities, once associated with turmeric, are due to curcumin.
Curcumin has been
shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal,
and anticancer activities and thus has a potential against various malignant
diseases, diabetes, allergies, arthritis, Alzheimer’s disease, and other
chronic illnesses. These effects are mediated through the regulationof various
transcription factors, growth factors, inflammatory cytokines,protein kinases,
and other enzymes. Curcumin exhibits activities similar to recently discovered
tumor necrosis factor blockers (e.g., HUMIRA, REMICADE, and ENBREL), a vascular
endothelial cell growth factor blocker (e.g., AVASTIN), human epidermal growth
factor receptor blockers (e.g., ERBITUX, ERLOTINIB, and GEFTINIB), and a HER2
blocker (e.g., HERCEPTIN). Considering the recent scientific bandwagon that
multitargeted therapy is better than monotargeted therapy for most diseases,
curcumin can be considered an ideal “Spice for Life”.
1. INTRODUCTION
The questions of
whether medicines discovered today are safer, more efficacious, and more
affordable than generic medicines (whose patents have expired) or medicines that
are centuries old could be answered “no” for most of the modern medicines. If
so, then it is logical to revisit and revive these age-old medicines for the
welfare of mankind. Curcumin is one such medicine. Its history goes back over
5000 years, to the heyday of Ayurveda (which means the science of long life).
Turmeric derived from the rhizome of the plant Curcuma longa has been used by
the people of the Indian subcontinent for centuries with no known side effects,
not only as a component of food but also to treat a wide variety of ailments.
Turmeric is a spice
of golden color that is used in cooking in the Indian subcontinent. Because of its color and taste, turmeric was
named “Indian saffron” in Europe. Today, India is the primary exporter of
turmeric (known as haldi in India). Although its ability to preserve food
through its antioxidant mechanism, to give color to food, and to add taste to
the food is well known, its health-promoting effects are less well recognized
or appreciated. It was once considered a cure for jaundice, an appetite
suppressant, and a digestive. In Indian and Chinese medicines, turmeric was
used as an anti-inflammatory agents to treat gas, colic, toothaches, chest
pains, and menstrual difficulties. This spice was also used to help with
stomach and liver problems, to heal wounds and lighten scars, and as a cosmetic.
Turmeric was
mentioned in the writings of Marco Polo concerning his 1280 journey to China
and India and it was first introduced to Europe in the 13th century
by Arab traders. Although Vasco de Gama (a Portugeese sailor) during 15th
century, after his visit to India, truly introduced spices to the West, it was
during the rule of British in India that turmeric was combined with various other
spices and renamed “curry powder,” as it is called in the West. What is there in turmeric that has therapeutic
potential, how does this substance mediate its effects, with what types of
receptor does it interact, and for what type of diseases is it effective? All
of these questions will be addressed in this
review.
2. COMPOSITION OF
TURMERIC
Turmeric contains a
wide variety of phytochemicals, including curcumin, demethoxycurcumin,
bisdemethoxycurcumin, zingiberene, curcumenol, curcumol, eugenol,
tetrahydrocurcumin, triethylcurcumin, turmerin, turmerones, and turmeronols. Curcumin,
demethoxycurcumin, and bisdemethoxycurcumin have also been isolated from
Curcuma mangga, Curcuma zedoaria, Costus speciosus,
Curcuma
xanthorrhiza, Curcuma aromatica, Cucruma phaeocaulis, Etlingera elatior, and
Zingiber cassumunar. Curcumin is the phytochemical that gives a yellow color to
turmeric and is now recognized as being responsible for most of the therapeutic
effects. It is estimated that 2–5% of turmeric is curcumin. Curcumin was first
isolated from turmeric in 1815, and the structure was delineated in 1910 as
diferuloylmethane. Most currently available preparations of curcumin contain
approximately 77% diferuloylmethane, 18% demethoxycurcumin, and 5%
bisdemethoxycurcumin. Curcumin is hydrophobic in nature and frequently soluble
in dimethylsulfoxide, acetone, ethanol, and oils. It has an absorption maxima
around 420 nm. When exposed to acidic conditions, the color of
turmeric/curcumin turns from yellow to deep red, the form in which it is used routinely
for various religious ceremonies.
3. CURCUMIN
ANALOGUES
As indicated
earlier, turmeric contains three different analogues of curcumin (i.e., diferuloylmethane,
also called curcumin, demethoxycurcumin, and bisdemothycurcumin. Whether all
three analogues exhibit equal activity is not clear. Although in most systems
curcumin was found to be most potent, in some systems bisdemethoxycurcumin was
found to exhibit higher activity. There are also suggestions that the mixture
of all three is more potent than either one alone. When administered orally, curcumin is
metabolized into curcumin glucuronide and curcumin sulfonate.13 However, when
administered systemically or intraperitoneally, it is metabolized into
tetrahydrocurcumin, hexhyrdrocurcumin, and hexhydrocurcuminol. Tetrahydrocurcumin has been shown to be
active in some systems and not in others. Whether other metabolites of curcumin
exhibit biological activity is not known.
4. USES OF CURCUMIN
The use of turmeric
for health purposes is nothing new. As a folklore medicine, its use has been
documented in both Indian and Chinese cultures. The long list of uses include
antiseptic, analgesic, anti-inflammatory, antioxidant, antimalarial,
insectrepellant, and other activities associated to turmeric. Perhaps one of
the most often prescribed uses is for wound-healing. This activity is well known
to people from the Indian subcontinent. Modern research has provided considerable
evidence, and the mechanism by which turmeric/curcumin could accelerate
wound-healing has been described.
It is now well
recognized that most chronic diseases are the result of disregulated
inflammation. Turmeric has been traditionally described as an anti-inflammatory
agent. Recent scientific evidence has indeed demonstrated that turmeric, and
curcumin in particular, exhibits potent anti-inflammatory activities as
determined by a wide variety of systems. Therefore, it is not too surprising that
turmeric displays activities against a variety of diseases. Because curcumin also
exhibits potent antioxidant activity, whether the anti-inflammatory activity of
curcumin is mediated through its antioxidant mechanism is not clear. Since most
well-characterized antioxidants do not exhibit antinflammatory activity, it is unlikely
that the anti-inflammatory activity of curcumin is due to its antioxidant activity.
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